Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer.

doi:10.1126/scitranslmed.ado1641

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Article

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer.

Science translational medicine - 21 May 2025

Grassi Elena, Vurchio Valentina, Cresswell George D, Catalano Irene, Lupo Barbara, Sassi Francesco, Galimi Francesco, Borgato Sofia, Ferri Martina, Viviani Marco, Pompei Simone, Urgese Gianvito, Chen Bingjie, Zanella Eugenia R, Cottino Francesca, Russo Mariangela, Mauri Gianluca, Pietrantonio Filippo, Zampino Maria Giulia, Lazzari Luca, Marsoni Silvia, Bardelli Alberto, Lagomarsino Marco Cosentino, Sottoriva Andrea, Trusolino Livio, Bertotti Andrea

Abstract excerpt

Historically, DNA sequence mutability has been considered relatively uniform and low in tumors with chromosomal instability (CIN), based on the assumption that high mutability would be detrimental in karyotypically aberrant contexts. Recent in silico analyses have challenged this view, suggesting some heterogeneity in mutation rates across CIN tumors; however, these predictions lack experimental validation. It...

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