Article

Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Pseudouridine (Ψ) is an abundant post-transcriptional modification found across all classes of RNA. It has been widely speculated that Ψ inclusion in mRNAs might provide an avenue for cells to control gene expression post-transcriptionally. Here we demonstrate that one of the principal mRNA pseudouridylating enzymes, pseudouridine synthase 7 (PUS7), exhibits a stress-induced accumulation in the...

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Literature Corpus work: 78e33e58-11e2-5e1e-8e4f-873353375792
DOI: 10.1101/2025.09.22.675887

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