Novel molecular insights into the critical role of sulfatide in myelin maintenance/function.

doi:10.1111/jnc.13738

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Article

Novel molecular insights into the critical role of sulfatide in myelin maintenance/function.

Journal of neurochemistry - 1 Oct 2016

Palavicini Juan Pablo, Wang Chunyan, Chen Linyuan, Ahmar Sareen, Higuera Juan Diego, Dupree Jeffrey L, Han Xianlin

Abstract excerpt

Cerebroside sulfotransferase (CST) catalyzes the production of sulfatide, a major class of myelin-specific lipids. CST knockout (CST(-/-) ) mice in which sulfatide is completely depleted are born healthy, but display myelin abnormalities and progressive tremors starting at 4-6 weeks of age. Although these phenotypes suggest that sulfatide plays a critical role in myelin maintenance/function, the underlying...

Topics

Animals
Axons
Homeostasis
Lipid Metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Myelin Proteins
Myelin Proteolipid Protein
Myelin Sheath
Myelin-Associated Glycoprotein
Oligodendroglia
Phenotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sulfoglycosphingolipids

Sulfotransferases

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Identifiers

PMID: 27417284
DOI: 10.1111/jnc.13738
PMCID: PMC5037006

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