Article

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

2022-04-27

Abstract excerpt

Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1 G93A mice. Evidence suggests that rescuing these deficits prevents disease progression, stops denervation, and extends survival. Kinase inhibitors have been previously identified as transport enhancers, and are being investigated as potential therapies for ALS. For ex...

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Literature Corpus work: 78dde1d2-373d-52e7-81f4-951332599603
DOI: 10.1101/2022.04.26.489550

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