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Article

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.

Cell reports - 17 Mar 2020

Sleigh James N, Tosolini Andrew P, Gordon David, Devoy Anny, Fratta Pietro, Fisher Elizabeth M C, Talbot Kevin, Schiavo Giampietro

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease resulting from a complex interplay between genetics and environment. Impairments in axonal transport have been identified in several ALS models, but in vivo evidence remains limited, thus their pathogenetic importance remains to be fully resolved. We therefore analyzed the in vivo dynamics of retrogradely transported,...

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Identifiers

PMID: 32187538
DOI: 10.1016/j.celrep.2020.02.078
PMCID: PMC7090381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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