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Article

Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase.

PloS one - 1 Jan 2013

Morfini Gerardo A, Bosco Daryl A, Brown Hannah, Gatto Rodolfo, Kaminska Agnieszka, Song Yuyu, Molla Linda, Baker Lisa, Marangoni M Natalia, Berth Sarah, Tavassoli Ehsan, Bagnato Carolina, Tiwari Ashutosh, Hayward Lawrence J, Pigino Gustavo F, Watterson D Martin, Huang Chun-Fang, Banker Gary, Brown Robert H, Brady Scott T

Abstract excerpt

Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined. Characteristics of motor neurons affected in FALS include abnormal kinase activation, aberrant neurofilament phosphorylation, and fast axonal transport (FAT)...

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Source

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Identifiers

PMID: 23776455
DOI: 10.1371/journal.pone.0065235
PMCID: PMC3680447

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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