Article

Evolution-Aware Deep Reinforcement Learning for Single-Cell DNA Copy Number Calling

2024-03-10

Abstract excerpt

Recent high-throughput single cell DNA sequencing technologies enable one to detect copy number aberrations (CNAs) on thousands of individual cells within a tumor. Several new methods enable haplotype-specific copy number calling on such data. However, these algorithms do not utilize evolutionary constraints, leading to the inference of spurious CNAs due to measurement noise that are inconsistent with a realistic...

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Literature Corpus work: 78d88968-4bf6-5eb2-9c5d-107c44c0253b
DOI: 10.1101/2024.03.08.583988

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