Article
The N-terminal 11 amino acids of human erythrocyte band 3 are critical for aldolase binding and protein phosphorylation: implications for band 3 function.
Blood - 15 Dec 2005
Perrotta Silverio, Borriello Adriana, Scaloni Andrea, De Franceschi Lucia, Brunati Anna Maria, Turrini Francesco, Nigro Vincenzo, del Giudice Emanuele Miraglia, Nobili Bruno, Conte Maria Luisa, Rossi Francesca, Iolascon Achille, Donella-Deana Arianna, Zappia Vincenzo, Poggi Vincenzo, Anong William, Low Philip, Mohandas Narla, Della Ragione Fulvio
Abstract excerpt
The 911 amino acid band 3 (SLC4A1) is the major intrinsic membrane protein of red cells and is the principal Cl-/HCO3- exchanger. The N-terminal cytoplasmic domain of band 3 anchors the spectrin-based membrane skeleton to the lipid bilayer through its interaction with ankyrin and also binds glycolytic enzymes and hemoglobin. We identified a son of a consanguineous marriage with severe anemia in association with...
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