Article
Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton.
Nature genetics - 1 Oct 1996
Southgate C D, Chishti A H, Mitchell B, Yi S J, Palek J
Abstract excerpt
Band 3 is the most abundant integral protein of the red blood cell membrane. It performs two critical biological functions: maintaining ionic homeostasis, by transporting Cl- and HCO3-ions, and providing mechanical stability to the erythroid membrane. Erythroid band 3 (AE1) is one of three anion...
Topics
- Alleles
- Anemia, Hemolytic
- Animals
- Anion Exchange Protein 1, Erythrocyte
- Cell Membrane
- Erythrocyte Membrane
- Erythrocytes
- Gene Targeting
- Genes
- Growth
- Homozygote
- Kidney
- Membrane Proteins
- Mice
- Mice, Mutant Strains
- Spherocytes
- Splenomegaly