Genomic analysis of oesophageal carcinoma (EC) identifies recurrent mutations in histone methyltransferases as a distinctive subset.

doi:10.1038/s41388-026-03897-4

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Genomic analysis of oesophageal carcinoma (EC) identifies recurrent mutations in histone methyltransferases as a distinctive subset.

Oncogene - 1 Sept 2026

Wang Jingyuan, Xiu Joanne, Battaglin Francesca, Arai Hiroyuki, Soni Shivani, Zhang Wu, Goldberg Richard M, Shields Anthony F, Grothey Axel, Hwang Jimmy J, Marshall John L, Astaturov Igor, Weinberg Benjamin A, Lou Emil, Hall Michael, Shroff Rachna T, Khushman Moh'd, Salem Mohamed E, Sohal Davendra P S, Scott Aaron J, Oberley Matt, Liu Tianshu, Shen Lin, Lenz Heinz-Josef

Abstract excerpt

Histone-lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone H3 tail at important regulatory regions in the genome and thereby impart crucial functions through modulating chromatin structures and DNA accessibility. We aimed to identify the molecular profile of KMT2-MT oesophageal cancer (EC) and associations with patient outcomes. In our study, KMT2 mutations were significantly...

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PMID: 42436343
DOI: 10.1038/s41388-026-03897-4
PMCID: PMC13457071

Genes

ATM
BRCA1
CIC
NF1

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