Back to search

Article

KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis

2022-04-08

Abstract excerpt

<h4>Background: </h4> Histone methyltransferase KMT2D is one of the most frequently mutated genes in diffuse large B-cell lymphoma (DLBCL) and has been identified as an important pathogenic factor and prognostic marker. However, the biological relevance of KMT2D mutations on tumor microenvironment remains to be determined. <h4>Methods: </h4> KMT2D mutations were assessed by whole-genome/exome sequencing (WGS/WES)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3dcc9d88-3af5-58e8-9d86-e4f9521a3c80
DOI
10.21203/rs.3.rs-1520534/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axisDOI 10.21203/rs.3.rs-1520534/v1
KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis.Semantic proximity
Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma.Semantic proximity
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axisSemantic proximity
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.Semantic proximity
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.Semantic proximity
Pan-Cancer Analysis of Histone Methyltransferase KMT2D with Potential Implications for Prognosis and Immunotherapy in Human CancerSemantic proximity
Mutational Profile and Clonal Evolution of Relapsed/Refractory Diffuse Large B-Cell LymphomaSemantic proximity
Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancersSemantic proximity
Molecular complexity of diffuse large B-cell lymphoma: a molecular perspective and therapeutic implications.Semantic proximity
Epigenetic Symphony in Diffuse Large B-Cell Lymphoma: Orchestrating the Tumor MicroenvironmentSemantic proximity
KMT2C is Potential Prognostic Biomarker and its Immune Regulating Roles in Pan-Cancer: A Comprehensive AnalysisSemantic proximity
Mutation status of the KMT2 family associated with immune checkpoint inhibitors (ICIs) therapy and implicating diverse tumor microenvironmentsSemantic proximity
Select a neighboring publication to make it the new centre.