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Article

Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p.

eLife - 22 Mar 2018

Khazina Elena, Weichenrieder Oliver

Abstract excerpt

LINE-1 (L1) is an autonomous retrotransposon, which acted throughout mammalian evolution and keeps contributing to human genotypic diversity, genetic disease and cancer. L1 encodes two essential proteins: L1ORF1p, a unique RNA-binding protein, and L1ORF2p, an endonuclease and reverse transcriptase. L1ORF1p contains an essential, but rapidly evolving N-terminal portion, homo-trimerizes via a coiled coil and...

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Topics

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Share to Crystallography, X-Ray
Share to Long Interspersed Nucleotide Elements
Share to Mutagenesis, Insertional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Protein Multimerization

Share to Ribonucleoproteins

Share to RNA-Binding Proteins

Share to Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 29565245
DOI: 10.7554/eLife.34960
PMCID: PMC5940361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p.PMID 29565245Read ↗

CO-EXPRESSION OF DISTINCT COILED COILS CAN LEAD TO THEIR ENTANGLEMENTSemantic proximity Read ↗

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