Article
Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature.
Frontiers in immunology - 1 Jan 2020
Kelkka Tiina, Savola Paula, Bhattacharya Dipabarna, Huuhtanen Jani, Lönnberg Tapio, Kankainen Matti, Paalanen Kirsi, Tyster Mikko, Lepistö Maija, Ellonen Pekka, Smolander Johannes, Eldfors Samuli, Yadav Bhagwan, Khan Sofia, Koivuniemi Riitta, Sjöwall Christopher, Elo Laura L, Lähdesmäki Harri, Maeda Yuka, Nishikawa Hiroyoshi, Leirisalo-Repo Marjatta, Sokka-Isler Tuulikki, Mustjoki Satu
Abstract excerpt
Rheumatoid arthritis (RA) is a complex autoimmune disease targeting synovial joints. Traditionally, RA is divided into seropositive (SP) and seronegative (SN) disease forms, the latter consisting of an array of unrelated diseases with joint involvement. Recently, we described a severe form of SN-RA that associates with characteristic joint destruction. Here, we sought biological characteristics to differentiate...
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