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Article

Pathogenic Citrulline‐Multispecific B Cell Receptor Clades in Rheumatoid Arthritis

21 Jun 2018

Abstract excerpt

OBJECTIVE: Anti-citrullinated protein antibodies (ACPAs) have proven highly useful as biomarkers for rheumatoid arthritis (RA). However, composition and functionality of the associated autoreactive B cell repertoire have not been directly assessed. We aimed to selectively investigate citrullinated autoantigen-specific B cell receptors (BCRs) involved in RA and initiate studies on their pathogenicity. METHODS:...

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PMID: 29927106
DOI: 10.1002/art.40590

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