Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes.

doi:10.1186/s13059-024-03210-0

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Article

Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes.

Genome biology - 11 Mar 2024

Aterido Adrià, López-Lasanta María, Blanco Francisco, Juan-Mas Antonio, García-Vivar María Luz, Erra Alba, Pérez-García Carolina, Sánchez-Fernández Simón Ángel, Sanmartí Raimon, Fernández-Nebro Antonio, Alperi-López Mercedes, Tornero Jesús, Ortiz Ana María, Fernández-Cid Carlos Marras, Palau Núria, Pan Wenjing, Byrne-Steele Miranda, Starenki Dmytro, Weber Daniel, Rodriguez-Nunez Ivan, Han Jian, Myers Richard M, Marsal Sara, Julià Antonio

Abstract excerpt

BACKGROUND: In rheumatoid arthritis (RA), the activation of T and B cell clones specific for self-antigens leads to the chronic inflammation of the synovium. Here, we perform an in-depth quantitative analysis of the seven chains that comprise the adaptive immune receptor repertoire (AIRR) in RA. RESULTS: In comparison to controls, we show that RA patients have multiple and strong differences in the B cell...

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PMID: 38468286
DOI: 10.1186/s13059-024-03210-0
PMCID: PMC10926600

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