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Article

Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles

2025-01-03

Abstract excerpt

Broad immune responses are needed to mitigate viral evolution and escape. To induce antibodies against conserved receptor-binding domain (RBD) regions of SARS-like betacoronavirus (sarbecovirus) spike proteins that recognize SARS-CoV-2 variants of concern and zoonotic sarbecoviruses, we developed mosaic-8b RBD-nanoparticles presenting eight sarbecovirus RBDs arranged randomly on a 60-mer nanoparticle. Mosaic-8b im...

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Identifiers and source

Literature Corpus work
786e4b2c-d8a6-58b6-8f4a-1f1c9233409b
DOI
10.1101/2025.01.02.631145
Open publication

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Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticlesDOI 10.1101/2025.01.02.631145
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