Article

Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody Responses

2025-12-10

Abstract excerpt

<title>Abstract</title> <p>Four seasonal endemic human coronaviruses (HCoVs), HCoV-HKU1, HCoV-OC43, HCoV-229E, and HCoV-NL63, are culprits of mild upper respiratory and periodic severe diseases in vulnerable populations. Despite their prevalence, understanding HCoVs’ antigenic and immune signatures remains elusive. SARS-CoV-2 has evolved as the fifth HCoV, requiring seasonal vaccination, and currently, no other H...

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Identifiers and source

Literature Corpus work: 565622e0-41d3-54e5-ac9b-8e3f48898239
DOI: 10.21203/rs.3.rs-7997313/v1

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