Article

Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines

2025-05-13

Abstract excerpt

Vaccines against emerging SARS-CoV-2 variants and sarbecoviruses with pandemic potential must elicit a robust humoral immune response in a population imprinted with the SARS-CoV-2 spike (S) protein. Here, we designed protein nanoparticle (NP) vaccines co-displaying the SARS-CoV-2 BA.5, SARS-CoV-1, and BtKY72 receptor-binding domains (RBDs) with or without the Wuhan-Hu-1 (Wu) RBD. We show that these vaccines elicit...

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Literature Corpus work: e83f4f3c-9f29-52f0-9b06-6e253a8669ca
DOI: 10.1101/2025.05.11.652904

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