Article

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

2022-06-28

Abstract excerpt

<h4>Summary</h4> Protection from SARS-related coronaviruses with spillover potential and SARS-CoV-2 variants could prevent and/or end pandemics. We show that mice immunized with nanoparticles co-displaying spike receptor-binding domains (RBDs) from eight sarbecoviruses (mosaic-8 RBD-nanoparticles) efficiently elicit cross-reactive anti-sarbecovirus antibodies against conserved class 1/4 and class 3 RBD epitopes....

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Literature Corpus work: a9ebe0f7-52c7-576f-96ef-82b4c0b4767b
DOI: 10.1101/2022.06.28.497989

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