Article
HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.
Molecular and cellular biology - 1 Jul 2005
Miele Angela, Braastad Corey D, Holmes William F, Mitra Partha, Medina Ricardo, Xie Ronglin, Zaidi Sayyed K, Ye Xin, Wei Yue, Harper J Wade, van Wijnen Andre J, Stein Janet L, Stein Gary S
Abstract excerpt
Genome replication in eukaryotic cells necessitates the stringent coupling of histone biosynthesis with the onset of DNA replication at the G1/S phase transition. A fundamental question is the mechanism that links the restriction (R) point late in G1 with histone gene expression at the onset of S phase. Here we demonstrate that HiNF-P, a transcriptional regulator of replication-dependent histone H4 genes,...
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