Article
Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.
Anesthesiology - 1 Jan 2007
Sonner James M, Werner David F, Elsen Frank P, Xing Yilei, Liao Mark, Harris R Adron, Harrison Neil L, Fanselow Michael S, Eger Edmond I, Homanics Gregg E
Abstract excerpt
BACKGROUND: Enhancement of the function of gamma-aminobutyric acid type A receptors containing the alpha1 subunit may underlie a portion of inhaled anesthetic action. To test this, the authors created gene knock-in mice harboring mutations that render the receptors insensitive to isoflurane while...
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