Article
Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain.
The Journal of comparative neurology - 1 Apr 2015
Wimmer Verena C, Harty Rosemary C, Richards Kay L, Phillips A Marie, Miyazaki Haruko, Nukina Nobuyuki, Petrou Steven
Abstract excerpt
The β1 subunit of voltage-gated sodium channels, Nav β1, plays multiple roles in neurons spanning electrophysiological modulation of sodium channel α subunits to cell adhesion and neurite outgrowth. This study used immunohistochemistry to investigate Nav β1 subneuronal and regional expression. Nav β1 was enriched at axon initial segments (AIS) and nodes of Ranvier. Nav β1 expression at the AIS was detected...
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