Article

Variable patterns of retrotransposition in different HeLa strains provide mechanistic insights into SINE RNA mobilization processes

2024-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Alu elements are non-autonomous Short INterspersed Elements (SINEs) derived from the 7SL RNA gene that are present at over one million copies in human genomic DNA. Alu mobilizes by a mechanism known as retrotransposition, which requires the Long INterspersed Element-1 (LINE-1 or L1) ORF2 -encoded protein (ORF2p). Here, we demonstrate that HeLa strains differ in their capacity to support Alu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78492599-7898-500f-baea-dda4066174cf
DOI: 10.1101/2024.05.03.592410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Variable patterns of retrotransposition in different HeLa strains provide mechanistic insights into SINE RNA mobilization processesDOI 10.1101/2024.05.03.592410Read

Identification of a minimal <i>Alu</i> domain required for retrotranspositionSemantic proximity Read

LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?Semantic proximity Read

Cis-acting influences on Alu RNA levels.Semantic proximity Read

Exploring Alu-Driven DNA Transductions in the Primate GenomesSemantic proximity Read

The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotranspositionSemantic proximity Read

Exogenous coronavirus interacts with endogenous retrotransposon in human cellsSemantic proximity Read

Active human retrotransposons: variation and disease.Semantic proximity Read

Active Alu retrotransposons in the human genome.Semantic proximity Read

Exploring <i>Alu</i> -Driven DNA Transductions in the Primate GenomesSemantic proximity Read

RNase L restricts the mobility of engineered retrotransposons in cultured human cellsSemantic proximity Read

Exogenous Coronavirus Interacts With Endogenous Retrotransposon in Human CellsSemantic proximity Read

Multiple fates of L1 retrotransposition intermediates in cultured human cells.Semantic proximity Read