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Article

Control of Gene Expression in Senescence through Transcriptional Read-Through of Convergent Protein-Coding Genes

1 Nov 2017

Abstract excerpt

Antisense RNAs are non-coding RNAs that can regulate their corresponding sense RNAs and are generally produced from specific promoters. We uncover here a family of antisense RNAs, named START RNAs, produced during cellular senescence by transcriptional read-through at convergent protein-coding genes. Importantly, START RNAs repress the expression of their corresponding sense RNAs. In proliferative cells, we found...

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PMID: 29186682
DOI: 10.1016/j.celrep.2017.11.006

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