Article

Two operational modes of atomic force microscopy reveal similar mechanical properties for homologous regions of dystrophin and utrophin

2024-05-20

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by the absence of the protein dystrophin. Dystrophin is hypothesized to work as a molecular shock absorber that limits myofiber membrane damage when undergoing reversible unfolding upon muscle stretching and contraction. Utrophin is a dystrophin homologue that is under investigation as a protein replacement therapy for DMD. However, it remains unc...

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Literature Corpus work: 77f4bf57-3f63-5c50-b189-d27845c11106
DOI: 10.1101/2024.05.18.593686

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Two operational modes of atomic force microscopy reveal similar mechanical properties for homologous regions of dystrophin and utrophinDOI 10.1101/2024.05.18.593686Read

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