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Article

Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy.

Proceedings of the National Academy of Sciences of the United States of America - 5 Nov 2013

Žoldák Gabriel, Stigler Johannes, Pelz Benjamin, Li Hongbin, Rief Matthias

Abstract excerpt

In this study we expand the accessible dynamic range of single-molecule force spectroscopy by optical tweezers to the microsecond range by fast sampling. We are able to investigate a single molecule for up to 15 min and with 300-kHz bandwidth as the protein undergoes tens of millions of folding/unfolding transitions. Using equilibrium analysis and autocorrelation analysis of the time traces, the full energetics...

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Identifiers

PMID: 24145407
DOI: 10.1073/pnas.1311495110
PMCID: PMC3831443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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