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Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity

2017-06-19

Abstract excerpt

Cells of multi-cellular organisms evolve toward uni-cellularity in the form of cancer and, if humans intervene, continue to evolve in cell culture. During this process, gene dosage relationships may evolve in novel ways to cope with the new environment and may regress back to the ancestral unicellular state. In this context, the evolution of sex chromosomes vis-a-vis autosomes is of particular interest. Here, we r...

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Literature Corpus work
77f44aee-812a-50eb-b25c-a0bdde96e2d5
DOI
10.1101/152223
Open publication

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