Article

From Multicellular Constraint to Unicellular Control: Cancer Evolves by Ancient Mechanisms of Genome Reconstruction, Repair, and Expansion

2025-08-08

Abstract excerpt

It is not widely known that the human genome retains ancestral emergency programs that can be activated in response to germline stress and irreparable DNA damage, freeing affected cells from the constraints of multicellularity. The reactivation of unicellular genome modules—via a process known as the multicellular-to-unicellular transition (MUT)—represents an ancient mechanism rooted in the gradual back-and-forth...

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Literature Corpus work: cd9da9d3-9621-5be5-94ed-9e9b541abc54
DOI: 10.20944/preprints202504.1112.v2

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