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Article

Regnase-1 D141N mutation induces CD4+ T cell-mediated lung granuloma formation via upregulation of Pim2.

International immunology - 10 Sept 2024

Htun Thin Sandi, Tanaka Hiroki, Singh Shailendra Kumar, Diez Diego, Akira Shizuo

Abstract excerpt

Regnase-1 is an RNase that plays a critical role in negatively regulating immune responses by destabilizing inflammatory messenger RNAs (mRNAs). Dysfunction of Regnase-1 can be a major cause of various inflammatory diseases with tissue injury and immune cell infiltration into organs. This study focuses on the role of the RNase activity of Regnase-1 in developing inflammatory diseases. We have constructed mice...

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PMID: 38700370
DOI: 10.1093/intimm/dxae026

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CD4

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