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The RNA binding protein Arid5a drives IL-17–dependent autoantibody-induced glomerulonephritis

18 Jun 2024

Abstract excerpt

Autoantibody-mediated glomerulonephritis (AGN) arises from dysregulated renal inflammation, with urgent need for improved treatments. IL-17 is implicated in AGN and drives pathology in a kidney-intrinsic manner via renal tubular epithelial cells (RTECs). Nonetheless, downstream signaling mechanisms provoking kidney pathology are poorly understood. A noncanonical RNA binding protein (RBP), Arid5a, was upregulated...

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PMID: 39058386
DOI: 10.1084/jem.20240656

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