Article
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis
2021-12-23
Abstract excerpt
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treat-ment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provided limited efficacy and an important burden of adverse events. Epigenetic drugs are a source of novel therapeutic tools. Among them, bromodomain and extraterminal domain (BET) inhibitors (iBETs) block the in...
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Identifiers and source
- Literature Corpus work
- 1ed4bd24-e0d0-53ff-b2ad-8032a344e6be
- DOI
- 10.20944/preprints202112.0290.v3