Article

Programmed Death-1 Deficiency Aggravates Motor Dysfunction In MPTP Model of Parkinson's Disease By Inducing Microglial Activation And Neuroinflammation In Mice

2021-11-01

Abstract excerpt

<title>Abstract</title> <p>Abundant reactive gliosis and neuroinflammation are typical pathogenetic hallmarks of brains in Parkinson’s disease (PD) patients, but regulation mechanisms are poorly understood. We are interested in role of programmed death-1 (PD-1) in glial reaction, neuroinflammation and neuronal injury in PD pathogenesis. Using PD mouse model and PD-1 knockout (KO) mice, we designed wild-type-contr...

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Literature Corpus work: 1b14c8e5-11aa-5c82-8d11-c3cb7f8ac68f
DOI: 10.21203/rs.3.rs-1023174/v1

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