Article

PD-1 Knockout Aggravates Motor Dysfunction In The MPTP Model of Parkinson's Disease By Inducing Microglial Activation And Neuroinflammation In Mice

2021-07-27

Abstract excerpt

<h4>Background: </h4> Abundant microglial reaction and neuroinflammation are typical pathogenetic hallmark of brains in Parkinson’s disease (PD) patients, but regulation mechanisms are poorly understood. In this study, the promoting effects of PD-1-difficiency on microglial activation, neuroinflammation and motor dysfunction were identified using PD animal model. <h4>Methods: </h4>: Using C57 wild-type (WT), PD-1...

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Literature Corpus work: 85ac1eaa-e48d-51c9-9d67-e79d2da55892
DOI: 10.21203/rs.3.rs-724934/v1

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