Article

<i>Txn1</i> mutation is a monogenic cause of chronic kidney disease associated with mitochondrial dysfunction in rats

2023-08-15

Abstract excerpt

Oxidative stress plays a significant role in the progression of chronic kidney disease. Thioredoxin 1 (Txn1) is one of the enzymatic antioxidants to regulate redox balance. However, the molecular mechanisms by Txn1 affects renal homeostasis remain unclear. This study aimed at elucidating the pathophysiology of Txn1 mutations in renal function. We used rats with the Txn1- F54L mutation generated by N-ethyl-N-nitr...

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Literature Corpus work: 77d98105-0608-5bfb-aab7-e070d6cc9457
DOI: 10.1101/2023.08.14.553187

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