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Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population

7 Feb 2023

Abstract excerpt

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we used a simple model of folic acid-induced kidney injury in 7 highly diverse mouse strains. We measured plasma and urine parameters, as well as renal...

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PMID: 36752209
DOI: 10.1172/jci.insight.164626

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