Article

Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation

2026-08-03

Abstract excerpt

<h4>Background and purpose</h4> Anthracyclines, such as doxorubicin (DOX), are associated with late-onset kidney dysfunction; however, the mechanisms underlying chronic tubular injury remain poorly understood. We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. <h4>Experimen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d681e009-91de-597b-a745-6dd9df5cb1ee
DOI: 10.64898/2026.07.29.741470

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of InflammationDOI 10.64898/2026.07.29.741470Read

<i>Txn1</i> mutation is a monogenic cause of chronic kidney disease associated with mitochondrial dysfunction in ratsSemantic proximity Read

Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease: From Molecular Mechanisms to Biomarkers and Targeted TherapiesSemantic proximity Read

Doxorubicin-Induced In Vivo Nephrotoxicity Involves Oxidative Stress- Mediated Multiple Pro- and Anti-Apoptotic Signaling PathwaysSemantic proximity Read

Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRsSemantic proximity Read

Harnessing mitochondrial biogenesis to combat acute kidney injury: Current insights and futuredirectionsSemantic proximity Read

SWATH-MS for discovery of early biomarkers of drug-induced cardiotoxicity using an animal doxorubicin modelSemantic proximity Read

Screening impacts of Tilmicosin induced-hepatic and renal toxicity in rats: Protection by Rhodiola Rosea extract through the involvement of oxidative stress, antioxidants, and inflammatory cytokines biomarkersSemantic proximity Read

Role of mitochondria in pathogenesis and therapy of renal fibrosisSemantic proximity Read

Chronic exposure to low-concentration urban PM2.5 accelerates maladaptive repair after ischemic injury via mitochondrial dysfunction and lysosomal stressSemantic proximity Read

PRMT4 interacts with NCOA4 to inhibit ferritinophagy in cisplatin-induced acute kidney injurySemantic proximity Read

Evaluation of toxicological mechanisms of ochratoxin-A in human primary proximal tubule epithelial cellsSemantic proximity Read

In Vivo RNA Interference Models of Inducible and Reversible Sirt1 Knockdown in Kidney CellsSemantic proximity Read