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Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility

29 Nov 2016

Abstract excerpt

The molecular signaling mechanisms between glomerular cell types during initiation/progression of diabetic kidney disease (DKD) remain poorly understood. We compared the early transcriptome profile between DKD-resistant C57BL/6J and DKD-susceptible DBA/2J (D2) glomeruli and demonstrated a significant downregulation of essential mitochondrial genes in glomeruli from diabetic D2 mice, but not in C57BL/6J, with...

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Advanced Glycation End Products research
Birth, Development, and Health
Chronic Kidney Disease and Diabetes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27899487
DOI: 10.2337/db16-0695

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