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Glutathione-specific gamma–glutamylcyclotransferase 1 ( CHAC1 ) increases kidney disease risk by modulating ferroptosis

23 Apr 2025

Abstract excerpt

Genome-wide association studies (GWASs) have identified more than 1000 loci where genetic variants correlate with kidney function. However, the specific genes, cell types, and mechanisms influenced by these genetic variants remain largely uncharted. Here, we identified glutathione-specific gamma–glutamylcyclotransferase 1 ( CHAC1 ) on chromosome 15 as affected by GWAS variants by analyzing human kidney gene...

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PMID: 40267214
DOI: 10.1126/scitranslmed.adn3079

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