Article

Loss of CDK12 drives renal lipotoxicity and fibrosis through NCEH1 intronic polyadenylation

2026-08-12

Abstract excerpt

Cyclin-dependent kinase 12 (CDK12) has been identified as a susceptibility locus for kidney function, but its role in chronic kidney disease (CKD) remains unclear. We generated tubule-specific CDK12 knockdown and overexpression mice and establish CKD models via adenine-induced and unilateral ureteral obstruction. We assessed renal injury, lipid metabolism, and transcriptional alterations using histology, functiona...

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Literature Corpus work: 77d03fa0-84a8-54ec-9e8a-7418f7cb432b
DOI: 10.1186/s13059-026-04239-z

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