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Article

EZH2 inhibition or genetic ablation suppresses cyst growth in autosomal dominant polycystic kidney disease

29 Oct 2024

Abstract excerpt

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a prevalent genetic disorder characterized by the formation of renal cysts leading to kidney failure. Despite known genetic underpinnings, the variability in disease progression suggests additional regulatory layers, including epigenetic modifications. We utilized various ADPKD models, including Pkd1 and Ezh2 conditional knockout ( Pkd1 delta/delta : Ezh2...

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PMID: 39472935
DOI: 10.1186/s12967-024-05785-5

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