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Genome-wide association studies identify the role of caspase-9 in kidney disease

5 Nov 2021

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of genetic risk regions for kidney dysfunction [estimated glomerular filtration rate (eGFR)]; however, the causal genes, cell types, and pathways are poorly understood. Integration of GWAS and human kidney expression of quantitative trait analysis using Bayesian colocations, transcriptome-wide association studies, and summary-based Mendelian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34739325
DOI: 10.1126/sciadv.abi8051

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