Article

SETD5 dysfunction in human astrocytes drives IL-6-mediated neuronal impairments via the JAK/STAT signaling pathway

2026-04-07

Abstract excerpt

Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental conditions marked by lifelong impairments in cognitive, motor, and social functions. Hundreds of genetic variants have been linked to these disorders, including mutations in chromatin regulators such as the SET-domain-containing protein 5 ( SETD5 ) gene. Most studies linking SETD5 loss-of-function to ASD/ID have focused primar...

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Literature Corpus work: 77c06052-4e67-5007-a3a8-9fa46c66401a
DOI: 10.64898/2026.04.05.716613

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