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Article

Role of astrocytes in the pathogenesis of perinatal brain injury

13 Aug 2025

Abstract excerpt

Astrocytes, the most abundant glial cells in the central nervous system (CNS), play critical roles in blood-brain barrier (BBB) maintenance, synaptogenesis, neurotransmission, and metabolic regulation. In response to perinatal brain injury, astrocytes release inflammatory mediators that drive neuroinflammation, disrupting normal brain development. Key signaling pathways, including Janus kinase/signal transducers...

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PMID: 40804657
DOI: 10.1186/s10020-025-01328-w

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