Article
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
PLoS genetics - 1 Jan 2012
Zou Fanggeng, Chai High Seng, Younkin Curtis S, Allen Mariet, Crook Julia, Pankratz V Shane, Carrasquillo Minerva M, Rowley Christopher N, Nair Asha A, Middha Sumit, Maharjan Sooraj, Nguyen Thuy, Ma Li, Malphrus Kimberly G, Palusak Ryan, Lincoln Sarah, Bisceglio Gina, Georgescu Constantin, Kouri Naomi, Kolbert Christopher P, Jen Jin, Haines Jonathan L, Mayeux Richard, Pericak-Vance Margaret A, Farrer Lindsay A, Schellenberg Gerard D, Petersen Ronald C, Graff-Radford Neill R, Dickson Dennis W, Younkin Steven G, Ertekin-Taner Nilüfer
Abstract excerpt
Genetic variants that modify brain gene expression may also influence risk for human diseases. We measured expression levels of 24,526 transcripts in brain samples from the cerebellum and temporal cortex of autopsied subjects with Alzheimer's disease (AD, cerebellar n=197, temporal cortex n=202) and with other brain pathologies (non-AD, cerebellar n=177, temporal cortex n=197). We conducted an expression...
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