Article
Genetic variability in the regulation of gene expression in ten regions of the human brain.
Nature neuroscience - 1 Oct 2014
Ramasamy Adaikalavan, Trabzuni Daniah, Guelfi Sebastian, Varghese Vibin, Smith Colin, Walker Robert, De Tisham, Coin Lachlan, de Silva Rohan, Cookson Mark R, Singleton Andrew B, Hardy John, Ryten Mina, Weale Michael E
Abstract excerpt
Germ-line genetic control of gene expression occurs via expression quantitative trait loci (eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions. We found that cis-eQTL signals (within 1 Mb of their target gene) were numerous, and many acted heterogeneously among regions and exons. Co-regulation analysis of shared eQTL signals produced well-defined modules of region-specific...
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