Article

Frequent functional orthology of long noncoding RNAs and genomic loci associated with complex traits and disorders

2025-11-02

Abstract excerpt

Genome wide association studies (GWAS) have identified many haplotype blocks linked to a wide range of complex human traits, including intelligence, neuropsychiatric disorders, and immunological disorders, among many others. Approximately a quarter of these haplotype blocks lack protein-coding sequences but most express long noncoding RNAs (lncRNAs). Here we show that human loci orthologous with mammalian lncRNAs...

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Literature Corpus work: 87870583-9ce0-569b-bae3-6fe60a7b8bbf
DOI: 10.1101/2025.10.31.25339260

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