Article

The Rad52 superfamily as seen by AlphaFold

2024-08-09

Abstract excerpt

1 Rad52, a highly conserved eukaryotic protein, plays a crucial role in DNA repair, especially in double-strand break repair. Recent findings reveal that its distinct structural features, including a characteristic β -sheet and β -hairpin motif, are shared with the lambda phage single-strand annealing proteins, Red β , indicating a common superfamily. Our analysis of over 10,000 single-strand annealing proteins...

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Literature Corpus work: 7798d13d-d50a-5987-952c-b4da06f6e52b
DOI: 10.1101/2024.08.09.607149

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