Article
The euryarchaeota, nature's medium for engineering of single-stranded DNA-binding proteins.
The Journal of biological chemistry - 15 Apr 2005
Robbins Justin B, McKinney Mary C, Guzman Claudia E, Sriratana Binjon, Fitz-Gibbon Sorel, Ha Taekjip, Cann Isaac K O
Abstract excerpt
The architecture of single-stranded DNA-binding proteins, which play key roles in DNA metabolism, is based on different combinations of the oligonucleotide/oligosaccharide binding (OB) fold. Whereas the polypeptide serving this function in bacteria contains one OB fold, the eukaryotic functional homolog comprises a complex of three proteins, each harboring at least one OB fold. Here we show that unlike these...
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