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<i>Mycobacterium tuberculosis</i> H <sub>2</sub> S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility

2021-06-02

Abstract excerpt

H 2 S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H 2 S has been shown to profoundly alter M. tuberculosis ( Mtb ) energy metabolism and growth. However, compelling evidence for endogenous production of H 2 S and its role in Mtb physiology is lacking. We show that multidrug-resistant and drug-susceptible clinical Mtb strains produce H 2 S, whereas H 2 S production in non-pathogeni...

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Literature Corpus work
b0f0fb7a-dcdd-5c48-9256-69c13b2f6a10
DOI
10.1101/2021.06.02.446746
Open publication

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