Article

GlycoVHH: Introducing N-glycans on the camelid VHH antibody scaffold - Optimal sites and use for macrophage delivery

2022-04-25

Abstract excerpt

As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VHHs, we explored the VHH scaffold in a structure-guided approach to select regions where the introduction of an N-glycosylation N-X-T sequon and its associated glycan should no...

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Literature Corpus work: 774e5205-a04f-53bf-a118-1020fe8216c8
DOI: 10.1101/2022.04.25.489312

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